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Biological Activities of Cyclic and Acyclic B-Type Laxaphycins in SH-SY5Y Human Neuroblastoma Cells

Alvariño Romero, Rebeca; Alonso López, Eva; Bornancin, Louis; Bonnard, Isabelle; Inguimbert, Nicolas; Banaigs, Bernard; Botana López, Luis Miguel (MDPI, 2020)

Laxaphycins are a family of non-ribosomal lipopeptides that have been isolated from several cyanobacteria. Some of these compounds have presented cytotoxic activities, but their mechanism of action is poorly understood. ...

Single and combined effects of regulated and emerging mycotoxins on viability and mitochondrial function of SH-SY5Y cells

Pérez Fuentes, Nadia; Alvariño Romero, Rebeca; Alfonso Rancaño, María Amparo; González Jartín, Jesús María; Gegunde Mosquera, Sandra; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (Elsevier, 2021)

Co-occurrence of emerging and regulated mycotoxins in contaminated samples has been widely documented, but studies about their combined toxicity are scarce. In this report, the regulated mycotoxins deoxynivalenol, fumonisin ...

Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius

Alves, Celso; Silva, Joana M.; Pinteus, Susete; Alonso López, Eva; Alvariño Romero, Rebeca; Duarte, Adriana; Marmitt, Diorge; Goettert, Márcia Inês; Gaspar, Helena; Alfonso Rancaño, María Amparo; Alpoim, Maria C.; Botana López, Luis Miguel; Pedrosa, Rui (MDPI, 2021)

Marine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study ...

Enniatins A1 and B1 alter calcium homeostasis of neuronal cells leading to apoptotic death

Enniatins (ENNs) A1 and B1 are non-regulated mycotoxins produced by Fusarium spp. that commonly occur in different types of food. These toxins are cytotoxic in several cell lines, but their mechanism of action is unclear. ...