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Single and combined effects of regulated and emerging mycotoxins on viability and mitochondrial function of SH-SY5Y cells

Pérez Fuentes, Nadia; Alvariño Romero, Rebeca; Alfonso Rancaño, María Amparo; González Jartín, Jesús María; Gegunde Mosquera, Sandra; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (Elsevier, 2021)

Co-occurrence of emerging and regulated mycotoxins in contaminated samples has been widely documented, but studies about their combined toxicity are scarce. In this report, the regulated mycotoxins deoxynivalenol, fumonisin ...

Combined Effect of Caspase-Dependent and Caspase-Independent Apoptosis in the Anticancer Activity of Gold Complexes with Phosphine and Benzimidazole Derivatives

Rouco Méndez, Lara; Sánchez González, María Ángeles; Alvariño Romero, Rebeca; Alfonso Rancaño, María Amparo; Vázquez López, Ezequiel M.; García Martínez, Emilia; Maneiro Maneiro, Marcelino (MDPI, 2021)

Since the potential anticancer activity of auranofin was discovered, gold compounds have attracted interest with a view to developing anticancer agents that follow cytotoxic mechanisms other than cisplatin. Two benzimidazole ...

Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius

Alves, Celso; Silva, Joana M.; Pinteus, Susete; Alonso López, Eva; Alvariño Romero, Rebeca; Duarte, Adriana; Marmitt, Diorge; Goettert, Márcia Inês; Gaspar, Helena; Alfonso Rancaño, María Amparo; Alpoim, Maria C.; Botana López, Luis Miguel; Pedrosa, Rui (MDPI, 2021)

Marine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study ...

Enniatins A1 and B1 alter calcium homeostasis of neuronal cells leading to apoptotic death

Enniatins (ENNs) A1 and B1 are non-regulated mycotoxins produced by Fusarium spp. that commonly occur in different types of food. These toxins are cytotoxic in several cell lines, but their mechanism of action is unclear. ...