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New Invertebrate Vectors for PST, Spirolides and Okadaic Acid in the North Atlantic
(MDPI, 2013)
The prevalence of poisoning events due to harmful algal blooms (HABs) has declined during the last two decades through monitoring programs and legislation, implemented mainly for bivalves. However, new toxin vectors and ...
New Gastropod Vectors and Tetrodotoxin Potential Expansion in Temperate Waters of the Atlantic Ocean
(MDPI, 2012)
Tetrodotoxin is a potent low weight marine toxin found in warm waters, especially of the Indian and Pacific Oceans. Intoxications are usually linked to the consumption of the puffer fish, although TTX was already detected ...
Yessotoxin, a Marine Toxin, Exhibits AntiAllergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model
(PLOS, 2016-12-14)
Yessotoxins (YTXs) are a group of marine toxins produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. They may have medical interest due to their potential role as ...
New Invertebrate Vectors of Okadaic Acid from the North Atlantic Waters—Portugal (Azores and Madeira) and Morocco
(MDPI, 2015)
Okadaic acid and its analogues are potent phosphatase inhibitors that cause Diarrheic Shellfish Poisoning (DSP) through the ingestion of contaminated shellfish by humans. This group of toxins is transmitted worldwide but ...
Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool
(Springer Nature, 2017)
Background
Zebrafish (Danio rerio) is a model organism that has emerged as a tool for cancer research, cancer being the second most common cause of death after cardiovascular disease for humans in the developed world. ...
Modeling the OEC with two new biomimetic models: preparations, structural characterization, and water photolysis studies of a Ba–Mn box type complex and a Mn4N6 Planar-diamond cluster
(MDPI, 2018)
The oxygen-evolving complex (OEC) is the native enzyme that catalyzes the oxidation of water in natural photosynthesis. Two new classes of manganese cluster complexes of formula Ba2Mn2L12(H3L1)2(CH3OH)4 1 and Mn4L26Cl2 2 ...
Computational model of adsorption for paralytic shellfish poisoning toxins (PSTs) on graphene surface
(MDPI, 2016)
Paralytic Shellfish Toxins (PSTs) are polar analytes, most of them with positive charges resulting in a charge-induced dipole at the graphene surface when they approach to it. Graphene is a novel material with great ...
New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish
(Nature Publishing Group, 2015)
Azaspiracid (AZA) poisoning was unknown until 1995 when shellfish harvested in Ireland caused illness
manifesting by vomiting and diarrhoea. Furtherin vivo/vitro studies showed neurotoxicity linked with AZA
exposure. ...
Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression
(MDPI, 2013)
In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach. Because several reports differ in the damage detected in different ...
Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model
(Impact Journals, 2016)
The marine environment constitutes an extraordinary resource for the discovery of new therapeutic agents. In the present manuscript we studied the effect of 3 different sponge derived guanidine alkaloids, crambescidine-816, ...