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New Invertebrate Vectors for PST, Spirolides and Okadaic Acid in the North Atlantic
(MDPI, 2013)
The prevalence of poisoning events due to harmful algal blooms (HABs) has declined during the last two decades through monitoring programs and legislation, implemented mainly for bivalves. However, new toxin vectors and ...
Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities
(MDPI, 2019)
Mesenchymal stem cells (MSCs) are present in all organs and tissues, playing a well-known
function in tissue regeneration. However, there is also evidence indicating a broader role of MSCs in
tissue homeostasis. In vivo ...
Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation
(MDPI, 2015)
Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Polysaccharides, such as chitosan and carrageenan, which have good binding capacity with ...
Effects of Brassicaceae Isothiocyanates on Prostate Cancer
(MDPI, 2016-05-12)
Despite the major progress made in the field of cancer biology, cancer is still one of the leading causes of mortality, and prostate cancer (PCa) is one of the most encountered malignancies among men. The effective management ...
New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
(Taylor & Francis, 2019)
The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for
complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic
cascades ...
A new potential nano-oncological therapy based on polyamino acid nanocapsules
(Elsevier, 2013-07)
A critical objective in cancer therapy is to reduce the systemic toxicity through the modification of the biodistribution of anticancer drugs. Herein, we disclose a new biodegradable nanocarrier, polyglutamic acid (PGA) ...
5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines
(PLOS, 2019)
The last fifteen years have seen the emergence and overflow into the drug scene of “superpotent” N-benzylated phenethylamines belonging to the “NBOMe” series, accompanied by
numerous research articles. Although N-benzyl ...
Exploring the efficiency of gallic acid-based dendrimers and their block copolymers with PEG as gene carriers
(Future Science, 2012-07-20)
The synthesis of a new family of amino-functionalized gallic acid-triethylene glycol (GATG) dendrimers and their block copolymers with polyethylene glycol (PEG) has recently being disclosed. In addition, these dendrimers ...
New Gastropod Vectors and Tetrodotoxin Potential Expansion in Temperate Waters of the Atlantic Ocean
(MDPI, 2012)
Tetrodotoxin is a potent low weight marine toxin found in warm waters, especially of the Indian and Pacific Oceans. Intoxications are usually linked to the consumption of the puffer fish, although TTX was already detected ...
Yessotoxin, a Marine Toxin, Exhibits AntiAllergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model
(PLOS, 2016-12-14)
Yessotoxins (YTXs) are a group of marine toxins produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. They may have medical interest due to their potential role as ...