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Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities
(MDPI, 2019)
Mesenchymal stem cells (MSCs) are present in all organs and tissues, playing a well-known
function in tissue regeneration. However, there is also evidence indicating a broader role of MSCs in
tissue homeostasis. In vivo ...
New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
(Taylor & Francis, 2019)
The design of multi-target directed ligands (MTDLs) is a valid approach for obtaining effective drugs for
complex pathologies. MTDLs that combine neuro-repair properties and block the first steps of neurotoxic
cascades ...
5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines
(PLOS, 2019)
The last fifteen years have seen the emergence and overflow into the drug scene of “superpotent” N-benzylated phenethylamines belonging to the “NBOMe” series, accompanied by
numerous research articles. Although N-benzyl ...
Glucosinolate-Degradation Products as Co-Adjuvant Therapy on Prostate Cancer in Vitro
(MDPI, 2019)
Glucosinolate-degradation products (GS-degradation products) are believed to be responsible for the anticancer effects of cruciferous vegetables. Furthermore, they could improve the efficacy and reduce side-effects of ...
Creme tópico de capsaicina (8%) para o tratamento da síndrome da dor miofascial
(Elsevier, 2019)
Justificativa:
A síndrome da dor miofascial é uma causa comum de dor musculoesquelética. O objetivo deste estudo foi avaliar a potencial ação analgésica de 8% do creme de capsaicina para uso tópico em pacientes com ...
Enzyme-Loaded Gel Core Nanostructured Lipid Carriers to Improve Treatment of Lysosomal Storage Diseases: Formulation and In Vitro Cellular Studies of Elosulfase Alfa-Loaded Systems
(MDPI, 2019)
Mucopolysaccharidosis IVA (Morquio A) is a rare inherited metabolic disease caused by
deficiency of the lysosomal enzyme N-acetylgalatosamine-6-sulfate-sulfatase (GALNS). Until now,
treatments employed included hematopoietic ...
Design of aerogels, cryogels and xerogels of Alginate: effect of molecular weight, gelation conditions and drying method on particles’ micromeritics
(MDPI, 2019)
[ENG]Processing and shaping of dried gels are of interest in several fields like alginate aerogel beads used as highly porous and nanostructured particles in biomedical applications. The physicochemical properties of the ...
Proteomic analysis in morquio a cells treated with immobilized enzymatic replacement therapy on nanostructured lipid systems
(MDPI, 2019)
[ENG]Morquio A syndrome, or mucopolysaccharidosis type IVA (MPS IVA), is a lysosomal storage disease due to mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. Systemic skeletal dysplasia and the related ...
Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function
(MDPI, 2019)
A balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia. Since the discovery of this ...
Artificial intelligence applied to flavonoid data in food matrices
(MDPI, 2019)
Increasing interest in constituents and dietary supplements has created the need for more
efficient use of this information in nutrition-related fields. The present work aims to obtain optimal
models to predict the total ...