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New Invertebrate Vectors for PST, Spirolides and Okadaic Acid in the North Atlantic

Silva, Marisa; Barreiro, Aldo; Rodríguez Villamayor, Paula; Otero Fuertes, María Paz; Azevedo, Joana; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2013)

The prevalence of poisoning events due to harmful algal blooms (HABs) has declined during the last two decades through monitoring programs and legislation, implemented mainly for bivalves. However, new toxin vectors and ...

New Invertebrate Vectors of Okadaic Acid from the North Atlantic Waters—Portugal (Azores and Madeira) and Morocco

Silva, Marisa; Rodríguez Filgueiras, Inés; Barreiro, Aldo; Kaufmann, Manfred; Neto, Ana Isabel; Hassouani, Meryem; Sabour, Brahim; Alfonso Rancaño, María Amparo; Botana López, Luis Miguel; Vasconcelos, Vitor (MDPI, 2015)

Okadaic acid and its analogues are potent phosphatase inhibitors that cause Diarrheic Shellfish Poisoning (DSP) through the ingestion of contaminated shellfish by humans. This group of toxins is transmitted worldwide but ...

Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression

Crespo Vieira, Andrés; Rubiolo Gaytán, Juan Andrés; López Alonso, Henar; Cifuentes Martínez, José Manuel; Alfonso Rancaño, María Amparo; Bermúdez Pose, Roberto; Otero Fuertes, María Paz; Rodríguez Vieytes, María Mercedes; Vega Lisi, Félix Víctor; Botana López, Luis Miguel (MDPI, 2013)

In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach. Because several reports differ in the damage detected in different ...

Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP

Fernández, Diego A.; Louzao Ojeda, María Carmen; Fraga, María; Vilariño del Río, Natalia; Rodríguez Vieytes, María Mercedes; Botana López, Luis Miguel (MDPI, 2014)

Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves. These ...

Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX

Fernández Ferreiro, Sara; Carrera González, María Cristina; Vilariño del Río, Natalia; Louzao Ojeda, María Carmen; Santamarina Pernas, Germán; González Cantalapiedra, Antonio; Botana López, Luis Miguel (MDPI, 2015)

Phycotoxins are marine toxins produced by phytoplankton that can get accumulated in filter feeding shellfish. Human intoxication episodes occur due to contaminated seafood consumption. Okadaic acid (OA) and dynophysistoxins ...

Evaluation of the impact of mild steaming and heat treatment on the concentration of okadaic acid, dinophysistoxin-2 and dinophysistoxin-3 in mussels

Rodríguez Filgueiras, Inés; Alfonso Rancaño, María Amparo; Antelo Queijo, Álvaro; Álvarez, Mercedes; Botana López, Luis Miguel (MDPI, 2016-06)

This study explores the effect of laboratory and industrial steaming on mussels with toxin concentrations above and below the legal limit. We used mild conditions for steaming, 100 ˝C for 5 min in industrial processing, ...