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The cerebral cavernous malformation 3 gene is necessary for senescence induction
(Wiley, 2015)Mutations in cerebral cavernous malformation 3 gene are knownto result in development of vascular malformations and haverecently been proposed to also give rise to meningiomas. Wereport in this study that lack of CCM3 ... -
Interaction of silver atomic quantum clusters with living organisms: bactericidal effect of Ag3 clusters mediated by disruption of topoisomerase–DNA complexes
(Royal Society of Chemistry, 2015)Essential processes for living cells such as transcription and replication depend on the formation of specific protein–DNA recognition complexes. Proper formation of such complexes requires suitable fitting between the ... -
Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression
(Oxford University Press, 2015)Background: Cumulative data indicate that the endocannabinoid system plays a major role in feeding behavior and energy balance. Genetic silencing of cannabinoid receptor type 1 (CB1) reduces body weight gain, independently ... -
Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice
(Nature Publishing Group, 2015)Brown and beige adipocytes recruitment in brown (BAT) or white adipose tissue, mainly in the inguinal fat pad (iWAT), meet the need for temperature adaptation in cold-exposure conditions and protect against obesity in face ... -
Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin
(Nature Publishing Group, 2015)It is currently accepted that ambient, non-genetic factors influence perinatal development and evoke structural and functional changes that may persist throughout life. Overfeeding and androgenization after birth are two ...
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