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Improvement of Duchenne muscular dystrophy phenotype following obestatin treatment
(Wiley, 2018)
Background This study was performed to test the therapeutic potential of obestatin, an autocrine anabolic factor regulating
skeletal muscle repair, to ameliorate the Duchenne muscular dystrophy (DMD) phenotype.
Methods ...
κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance
(MDPI, 2021)
Several studies have reported that nicotine, the main bioactive component of tobacco, exerts a marked negative energy balance. Apart from its anorectic action, nicotine also modulates energy expenditure, by regulating brown ...
Glucagon control on food intake and energy balance
(MDPI, 2019)
Glucagon exerts pleiotropic actions on energy balance and has emerged as an attractive target for the treatment of diabetes and obesity in the last few years. Glucagon reduces body weight and adiposity by suppression of ...
Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation
(PLOS, 2011)
The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine ...
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis
(Elsevier, 2021)
Objective: Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty ...
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
(Elsevier, 2021)
Non-alcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases, including non-alcoholic steatohepatitis (NASH), cirrhosis, ...
Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis
(Elsevier, 2022)
One of the most common types of fibrotic liver occurs in patients with non-alcoholic fatty liver disease (NAFLD), which may develop into non-alcoholic steatohepatitis (NASH). Hepatic stellate cells (HSCs) are the primary ...
Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake
(MDPI, 2018)
Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein ...
Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency
(Nature Publishing Group, 2015)
The NR4A is a subfamily of the orphan nuclear receptors (NR) superfamily constituted by three well characterized members: Nur77 (NR4A1), Nurr1 (NR4A2) and Nor 1 (NR4A3). They are implicated in numerous biological processes ...
Central nicotine induces browning through hypothalamic κ opioid receptor
(Nature Publishing Group, 2019)
[ENG]Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding ...