Now showing items 21-40 of 306

    • Population-based versus hospital-based controls: are they comparable? 

      Ruano Raviña, Alberto; Pérez Ríos, Mónica; Barros Dios, Juan Miguel (Elsevier, 2008)
      Objective:To compare whether there are differences amonghospital and population controls. Methods:Two case-control studies were conducted on lungcancer risk factors in the Santiago de Compostela Public Health ...
    • Reference genes for normalization of gene expression studies in human osteoarthritic articular cartilage 

      Pombo Suárez, Manuel Enrique; Calaza Cabanas, Manuel; Gómez-Reino Carnota, Juan Jesús; González Martínez-Pedrayo, Antonio (BMC, 2008)
      Background Assessment of gene expression is an important component of osteoarthritis (OA) research, greatly improved by the development of quantitative real-time PCR (qPCR). This technique requires normalization for precise ...
    • Indicadores de calidad de la prescripción en dosis diarias definidas. ¿Lo estamos haciendo bien? 

      Caamaño Isorna, Francisco; Álvarez Gil, Rosa (Elsevier, 2008)
      Los indicadores de la calidad de la prescripción de grado potencial de uso (IGPU) se definen como la proporción que representa el consumo de determinados principios activos frente al consumo total de su categoría anatómica ...
    • Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancer: a HuGE-GSEC review 

      Varela Lema, María Leonor; Taioli, Emanuela; Ruano Raviña, Alberto; Barros Dios, Juan Miguel; Anantharaman, Devasena; Benhamou, Simone; Boccia, Stefania; Bhisey, Rajani A.; Cadoni, Gabriella; Capoluongo, Ettore; Chen, Chien-Jen; Foulkes, William D.; Goloni Bertollo, Eny Maria; Hatagima, Ana; Hayes, Richard B.; Katoh, Takahiko; Koifman, Sergio; Lazarus, Phillip; Manni, Johannes J.; Mahimkar, Manoj; Morita, Shunji; Park, Jong; Park, Kwang-Kyun; Pavarino Bertelli, Erika Cristina; Ribeiro, Enilze Maria de Souza Fonseca; Roy, Bidyut; Spitz, Margaret R.; Strange, Richard C.; Wei, Qingyi; Ragin, Camille C. (Nature Publishing Group, 2008)
      The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control ...
    • Impact of the spanish smoking law on exposure to second-hand smoke and respiratory health in hospitality workers: a cohort study 

      Fernández, Esteve; Fu, Marcela; Pascual, José A.; López, María J.; Pérez Ríos, Mónica; Schiaffino, Anna; Martínez Sánchez, José M.; Ariza, Carles; Saltó, Esteve; Nebot, Manuel (PLOS, 2009)
      A smoke-free law came into effect in Spain on 1st January 2006, affecting all enclosed workplaces except hospitality venues, whose proprietors can choose among totally a smoke-free policy, a partial restriction with ...
    • c-Src regulates akt signaling in response to ghrelin via β-arrestin signaling-independent and -dependent mechanisms 

      Lodeiro, Maria; Theodoropoulou, Marily; Pardo Pérez, María; Casanueva Freijo, Felipe; Pérez Camiña, Jesús (PLOS, 2009)
      The aim of the present study was to identify the signaling mechanisms to ghrelin-stimulated activation of the serine/threonine kinase Akt. In human embryonic kidney 293 (HEK293) cells transfected with GHS-R1a, ghrelin leads ...
    • El cáncer de pulmón como marcador de tabaquismo: relación con la mortalidad por cáncer no pulmonar 

      Pérez Ríos, Mónica; Leistikow, Bruce; Montes Martínez, Agustín (Elsevier, 2009)
      Objetivo Valorar el papel del tabaquismo, empleando como proxy la mortalidad por cáncer de pulmón, en la mortalidad por otros cánceres (excluyendo el de estómago). Métodos Análisis de series temporales de mortalidad ...
    • Fundamentos y aplicaciones del diseño de casos cruzados 

      Carracedo Martínez, Eduardo; Tobías, Aurelio; Saez, Marc; Taracido Trunk, Margarita; Figueiras Guzmán, Adolfo (Elsevier, 2009)
      El diseño de casos cruzados es un diseño epidemiológico observacional propuesto por Maclure en 1991 para valorar si alguna exposición intermitente o inusual ha desencadenado un evento agudo a muy corto plazo. En este trabajo ...
    • Prevalence of dementia and major dementia subtypes in Spanish populations: A reanalysis of dementia prevalence surveys, 1990-2008 

      Pedro Cuesta, Jesús de; Virués Ortega, Javier; Vega, Saturio; Seijo Martínez, Manuel; Saz, Pedro; Rodríguez, Fernanda; Rodríguez Laso, Ángel; Reñé, Ramón; Pérez de las Heras, Susana; Mateos, Raimundo; Martínez Martín, Pablo; Marubens, José María; Mahillo Fernández, Ignacio; López Pousa, Secundino; Lobo, Antonio; Llinàs Reglà, Jordi; Gascón, Jordi; García, Francisco José; Fernández Martínez, Manuel; Boix, Raquel; Bermejo Pareja, Félix; Bergareche, Alberto; Benito León, Julián; Arce, Ana de; Barrio, José Luis del (BMC, 2009)
      Background This study describes the prevalence of dementia and major dementia subtypes in Spanish elderly. Methods We identified screening surveys, both published and unpublished, in Spanish populations, which fulfilled ...
    • Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study 

      Suárez Gestal, María de los Ángeles; Calaza Cabanas, Manuel; Endreffy, Emöke; Pullmann, Rudolf; Ordi Ros, Josep; Sebastiani, Gian Domenico; Ruzickova, Sarka; Santos, María José; Papasteriades, Chryssa; Marchini, Maurizio; Skopouli, Fotini N.; Suárez, Ana; Blanco, Francisco J.; D'Alfonso, Sandra; Bijl, Marc; Carreira, Patricia; Witte, Torsten; Migliaresi, Sergio; Gómez-Reino Carnota, Juan Jesús; González Martínez-Pedrayo, Antonio; European Consortium of SLE DNA Collections (BMC, 2009)
      Introduction We aimed to replicate association of newly identified systemic lupus erythematosus (SLE) loci. Methods We selected the most associated SNP in 10 SLE loci. These 10 SNPs were analysed in 1,579 patients ...
    • DAS-28-based EULAR response and HAQ improvement in rheumatoid arthritis patients switching between TNF antagonists 

      Navarro Sarabia, Federico; Ruiz Montesinos, Dolores; Hernández, Blanca; Navarro Compán, Victoria; Marsal, Sara; Barcelo, Mireia; Pérez Pampín, Eva; Gómez-Reino Carnota, Juan Jesús (BMC, 2009)
      Introduction No definitive data are available regarding the value of switching to an alternative TNF antagonist in rheumatoid arthritis patients who fail to respond to the first one. The aim of this study was to evaluate ...
    • Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility 

      Diéguez González, Rebeca; Calaza Cabanas, Manuel; Pérez Pampín, Eva; Balsa, Alejandro; Blanco, Francisco J.; Cañete, Juan D.; Cáliz, Rafael; Carreño, Luis; Serna, Arturo R. de la; Fernández Gutiérrez, Benjamín; Ortiz, Ana María; Herrero Beaumont, Gabriel; Pablos, Jose L.; Narváez, Javier; Navarro, Federico; Marenco, Jose L.; Gómez-Reino Carnota, Juan Jesús; González Martínez-Pedrayo, Antonio (BMC, 2009)
      Introduction Genome-wide association studies of rheumatoid arthritis (RA) have identified an association of the disease with a 6q23 region devoid of genes. TNFAIP3, an RA candidate gene, flanks this region, and polymorphisms ...
    • Fagerstrom test for nicotine dependence vs heavy smoking index in a general population survey 

      Pérez Ríos, Mónica; Santiago Pérez, María Isolina; Alonso, Begoña; Malvar Pintos, Alberto; Hervada Vidal, Xurxo; Leon, J. de (BMC, 2009)
      Background The Fagerström Test for Nicotine Dependence (FTND) is used for assessing nicotine dependence. A shorter test derived from the FTND used for the general population is the Heavy Smoking Index (HSI) (six questions ...
    • A Viral Infection Model with a Nonlinear Infection Rate 

      Yu, Yumei; Nieto Roig, Juan José; Torres Iglesias, Ángela Juana; Wang, Kaifa (SpringerOpen, 2009)
      A viral infection model with a nonlinear infection rate is constructed based on empirical evidences. Qualitative analysis shows that there is a degenerate singular infection equilibrium. Furthermore, bifurcation of cusp-type ...
    • Efecto de las desigualdades socioeconómicas en la mortalidad de la ciudad de Fortaleza, Ceará, Brasil durante el año 2007 

      Oliveira, Danila Carneiro de; Salgado Barreira, Ángel; Taracido Trunk, Margarita; Figueiras Guzmán, Adolfo (Ministerio de Sanidad, Consumo y Bienestar social, 2010)
      Fundamentos: Brasil es un ejemplo para estudiar la situación de la pobreza y sus determinantes, ya que posee una gran parte de la población pobre de América Latina y presenta gran potencial para erradicar esta pobreza. El ...
    • Development and use of touch -screen computer- asisted self interviewing in portuguese patients wit chronic immune diseases : evaluation of an electronic version OF SF - 3 6 V 2 

      Ribeiro, Claudia; Moreira, Luis; Silveira, Augusta; Silva, Isabel; Gestal Otero, Juan Jesús; Vasconcelos, Carlos (Sociedade Portuguesa de Reumatologia, 2010)
      Aim:The major purpose of this study was to evaluate alternative automated methods of collecting data on health related quality of life (HR-QoL). In order to achieve this, we developed a study with the following objectives: ...
    • Cambios en las expectativas y las actitudes de los trabajadores de la hostelería después de la ley de medidas sanitarias frente al tabaquismo 

      Martínez Sánchez, José M.; Fernández, Esteve; Fu, Marcela; Pérez Ríos, Mónica; Schiaffino, Anna; López, María J.; Alonso, Begoña; Saltó, Esteve; Nebot, Manel; Borràs, Josep M.; Grupo de Evaluación de la Ley sobre medidas sanitarias frente al tabaquismo (Elsevier, 2010)
      Objetivo Evaluar los cambios en las expectativas y las actitudes sobre la Ley 28/2005 de medidas sanitarias frente al tabaquismo de los trabajadores de la hostelería tras 2 años de su entrada en vigor. Métodos Estudio ...
    • Risky alcohol use and heavy episodic drinking among Spanish university students: A two-year follow-up 

      Mota Miranda, Nayara Graciella; Álvarez Gil, Rosa; Corral Varela, María Montserrat; Rodríguez Holguín, Socorro; Parada Iglesias, María; Crego Barreiro, Manuel Alberto; Caamaño Isorna, Francisco; Cadaveira Mahía, Fernando (Elsevier España, S.L.Sociedad Española de Salud Pública y Administración Sanitaria (SESPAS), 2010)
      Objective: To evaluate the incidence of risky consumption (RC) and heavy episodic drinking (HED) in the Cohort of Spanish university students at two-year follow-up and to identify predictors of these patterns of alcohol ...
    • Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model 

      García, Samuel; Forteza Vila, Jerónimo; López Otin, Carlos; Gómez-Reino Carnota, Juan Jesús; González Martínez-Pelayo, Antonio; Conde, Carmen (BMC, 2010)
      Introduction Rheumatoid arthritis is an autoimmune disease in which joint inflammation leads to progressive cartilage and bone erosion. Matrix metalloproteinases (MMPs) implicated in homeostasis of the extracellular matrix ...
    • Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study 

      Suárez Gestal, María de los Ángeles; Pérez Pampín, Eva; Calaza Cabanas, Manuel; Gómez-Reino Carnota, Juan Jesús; González Martínez-Pedrayo, Antonio (BMC, 2010)
      Introduction We aimed to replicate the strong associations that a recent genome wide association study (GWAS) has found between 16 single nucleotide polymorphisms (SNPs) and response to anti-tumour necrosis factor (TNF) ...





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