Now showing items 1-10 of 195
Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning
Type-2 Familial Partial Lipodystrophy is caused by LMNA mutations. Patients gradually lose subcutaneous fat from the limbs, while they accumulate adipose tissue in the face and neck. Several studies have demonstrated that ...
Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also ...
Prevalence of canine heartworm (Dirofilaria immitis) disease in dogs of central Portugal
(EDP Sciences, 2014)
The aim of the present study was to determine the prevalence and risk factors concerning Dirofilaria immitis infection in dogs from Figueira da Foz, located in the central region of Portugal. In the period between ...
Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy
(Frontiers Media, 2018)
Acquired generalized lipodystrophy (AGL) is a rare condition characterized by an altered distribution of adipose tissue and predisposition to develop hepatic steatosis and fibrosis, diabetes, and hypertriglyceridemia. ...
Primary versus secondary source of data in observational studies and heterogeneity in meta-analyses of drug effects: a survey of major medical journals
Background The data from individual observational studies included in meta-analyses of drug effects are collected either from ad hoc methods (i.e. “primary data”) or databases that were established for non-research purposes ...
Pegvisomant-Induced Cholestatic Hepatitis in an Acromegalic Patient with UGT1A1∗ 28 Mutation
Pegvisomant (PEGv) is a growth hormone receptor antagonist approved for the treatment of acromegaly; one of its documented adverse effects is reversible elevation of hepatic enzymes. We report a 39-year-old male acromegalic ...
Heavy drinking and non-medical use of prescription drugs among university students: a 9-year follow-up
Purpose: Investigations suggest non-medical use of prescription drugs (NMUPD) is associated with heavy drinking and polydrug use among university students. Our aim is to determine the prevalence of NMUPD among university ...
Identification of new putative driver mutations and predictors of disease evolution in chronic lymphocytic leukemia
(Nature Publishing Group, 2019)
Misconduct as the main cause for retraction. A descriptive study of retracted publications and their authors
Objective : To analyze the causes of retracted publications and the main characteristics of their authors. Method : A descriptive cross-sectional study was designed including all retracted publications from January 1st, ...
Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins.
(Nature Publishing Group, 2016-03-03)
The growth hormone secretagogue receptor, GHSR1a, mediates the biological activities of ghrelin, which includes the secretion of growth hormone, as well as the stimulation of appetite, food intake and maintenance of energy ...