Neuroendocrine pathways at risk? Simvastatin induces inter and transgenerational disruption in the keystone amphipod Gammarus locusta
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Título: | Neuroendocrine pathways at risk? Simvastatin induces inter and transgenerational disruption in the keystone amphipod Gammarus locusta |
Autor/a: | Neuparth, Teresa Alves, Nélson Machado, Andrade M. Pinheiro, Marlene Montes Goyanes, Rosa María Rodil Rodríguez, María del Rosario Barros, Susana Ruivo, Raquel Castro, Luis Filipe Quintana Álvarez, José Benito Santos, Miguel Machado |
Centro/Departamento: | Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía Universidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias |
Palabras chave: | Simvastatin | Gammarus locusta | Neuroendocrine signaling pathways | Transcriptomic | Inter and transgenerational effects | Regulatory agencies | |
Data: | 2022 |
Editor: | Elsevier |
Cita bibliográfica: | T. Neuparth et al. Aquatic Toxicology, 2022, 244, 106095 |
Resumo: | The primary focus of environmental toxicological studies is to address the direct effects of chemicals on exposed organisms (parental generation – F0), mostly overlooking effects on subsequent non-exposed generations (F1 and F2 – intergenerational and F3 transgenerational, respectively). Here, we addressed the effects of simvastatin (SIM), one of the most widely prescribed human pharmaceuticals for the primary treatment of hypercholesterolemia, using the keystone crustacean Gammarus locusta. We demonstrate that SIM, at environmentally relevant concentrations, has significant inter and transgenerational (F1 and F3) effects in key signaling pathways involved in crustaceans’ neuroendocrine regulation (Ecdysteroids, Catecholamines, NO/cGMP/PKG, GABAergic and Cholinergic signaling pathways), concomitantly with changes in apical endpoints, such as depressed reproduction and growth. These findings are an essential step to improve hazard and risk assessment of biological active compounds, such as SIM, and highlight the importance of studying the transgenerational effects of environmental chemicals in animals’ neuroendocrine regulation |
Versión do editor: | http://dx.doi.org/10.1016/j.aquatox.2022.106095 |
Data de Embargo: | 2024-01-25 |
URI: | http://hdl.handle.net/10347/29220 |
DOI: | 10.1016/j.aquatox.2022.106095 |
ISSN: | 0166-445X |
Dereitos: | © 2022, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Coleccións
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- ChromChem-Artigos [83]
- QANB-Artigos [325]
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