Mostrar o rexistro simple do ítem

dc.contributor.authorPorto González, Vanesa
dc.contributor.authorBuceta Fernández, David
dc.contributor.authorDomínguez Loidi, Blanca
dc.contributor.authorCarneiro Freire, María del Carmen
dc.contributor.authorBorrajo Alonso, Erea
dc.contributor.authorFraile Piñeiro, María
dc.contributor.authorDavila Ferreira, Nerea
dc.contributor.authorRodríguez Arias, Iria
dc.contributor.authorBlanco Trillo, José Manuel
dc.contributor.authorBlanco Varela, María del Carmen
dc.contributor.authorDevida, Juan Marcelo
dc.contributor.authorGiovanetti, Lisandro José
dc.contributor.authorRequejo, Félix Gregorio
dc.contributor.authorHernández Garrido, Juan Carlos
dc.contributor.authorCalvino Gámez, José Juan
dc.contributor.authorLópez Haro, Miguel
dc.contributor.authorBarone, Giampaolo
dc.contributor.authorJames, Andrew M.
dc.contributor.authorGarcía-Caballero Parada, Tomás
dc.contributor.authorGonzález Castaño, Diego Miguel
dc.contributor.authorTreder, Martin
dc.contributor.authorHuber, Wolfgang
dc.contributor.authorVidal Figueroa, Anxo
dc.contributor.authorMichael, P. Murphy
dc.contributor.authorLópez Quintela, Manuel Arturo
dc.contributor.authorDomínguez Puente, Fernando Ignacio
dc.date.accessioned2022-09-19T11:19:51Z
dc.date.available2022-09-19T11:19:51Z
dc.date.issued2022
dc.identifier.citationPorto, V., Buceta, D., Domínguez, B., Carneiro, C., Borrajo, E., Fraile, M., . . . Domínguez, F. (2022). Silver clusters of five atoms as highly selective antitumoral agents through irreversible oxidation of thiols. Advanced Functional Materials, 32(29), 2113028-n/a
dc.identifier.issn1616-301X
dc.identifier.urihttp://hdl.handle.net/10347/29229
dc.description.abstractLow atomicity clusters present properties dependent on the size, due to the quantum confinement, with well-defined electronic structures and high stability. Here it is shown that Ag5 clusters catalyze the complete oxidation of sulfur to S+6. Ag5 catalytic activity increases with different oxidant species in the order O2 ≪ H2O2 < OH•. Selective oxidation of thiols on the cysteine residues of glutathione and thioredoxin is the primary mechanism human cells have to maintain redox homeostasis. Contingent upon oxidant concentration, Ag5 catalyzes the irreversible oxidation of glutathione and thioredoxin, triggering apoptosis. Modification of the intracellular environment to a more oxidized state to mimic conditions within cancer cells through the expression of an activated oncogene (HRASG12V) or through ARID1A mutation, sensitizes cells to Ag5 mediated apoptosis. While cancers evolve to evade treatments designed to target pathways or genetic mutations that drive them, they cannot evade a treatment that takes advantage of aberrant redox homeostasis, which is essential for tumor progression and metastasis. Ag5 has antitumor activity in mice with orthotopic lung tumors reducing primary tumor size, and the burden of affected lymphatic nodes. The findings suggest the unique intracellular redox chemistry of Ag5 may lead to new redox-based approaches to cancer therapy
dc.description.sponsorshipThis research was partially supported by 1) “la Caixa” Foundation, Ref. LCF/PR/PR12/11070003 to F.D. and M.A.L.Q.; 2) Ministerio de Ciencia, Innovación y Universidades (MAT2017-89678-R, AEI/FEDER, UE) to F.D. and A.V.; 3) the Consellería de Educación (Xunta de Galicia), Grants No. Grupos Ref. Comp. ED431C 2017/22, ED431C 2019/13 and AEMAT-ED431E2018/08 to M.A.L.Q.; and ED431C 2019/13 to A.V. This project has received funding from the European Union's Horizon 2020 Research and Innovation Programme (Bac-To-Fuel) under Grant Agreement No. 825999 (M.A.L.Q.). J.C.H. acknowledge financial support from European Union's Horizon 2020 research and innovation programme under grant agreement no. 823717-ESTEEM3, and the MICIIN (projects PID2019-107578GA-100 and PID-110018GA-100). J.M.D, L.J.G., and F.G.R. thank to the ANPCyT (PICT 2015-2285 and 2017-3944), UNLP (Project 11/X790) and the partial support by the Laboratório Nacional de Luz Síncrotron (LNLS, Brazil) under proposal SXS-20180280. G.B. acknowledges the CINECA Award N. IsC51, year 2017, under the ISCRA initiative, for the availability of high-performance computing resources and support. D.B. expresses gratitude for a postdoctoral grant from Xunta de Galicia, Spain (POS-A/2013/018). B.D. expresses gratitude for a predoctoral grant from MICINN, Spain (BES-2016-076765). F.D. and A.V. also acknowledged Xunta de Galicia (Centro singular de investigación de Galicia accreditation 2019-2022 ref ED431G 2019/02) and the European Union (European Regional Development Fund – ERDF). Work in M.P.M.'s lab was supported by the Medical Research Council UK (MC_U105663142). T.G.C. gratefully acknowledges the technical assistance of María José Otero-Fraga (FIDIS)
dc.language.isoeng
dc.publisherWiley
dc.rights© 2022 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
dc.rightsAtribución 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCancer therapy
dc.subjectCatalysis
dc.subjectLow atomicity clusters
dc.subjectSilver clusters
dc.subjectSulfur oxidation
dc.titleSilver clusters of five atoms as highly selective antitumoral agents through irreversible oxidation of thiols
dc.typejournal article
dc.identifier.doi10.1002/adfm.202113028
dc.relation.publisherversionhttps://doi.org/10.1002/adfm.202113028
dc.type.hasVersionVoR
dc.identifier.essn1616-3028
dc.rights.accessRightsopen access
dc.contributor.affiliationUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Fisioloxía
dc.contributor.affiliationUniversidade de Santiago de Compostela. Departamento de Química Física
dc.description.peerreviewedSI
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/825999
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/ PID2019-107578GA-I00/ES/COMBINACION DE PLASMONICA Y CATALISIS PARA EL DESARROLLO DE NANOESTRUCTURAS BASADAS EN MOS2 PARA APLICACIONES DE ENERGIA LIMPIA
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-89678-R/ES/CLUSTERS ATOMICOS CUANTICOS DE PLATA: MECANISMOS DE ACCION BIOLOGICA Y APLICACIONES TERAPEUTICAS


Ficheiros no ítem

application/pdf
Nome: Artigo de investigación
Tamaño: 3.821 Mb
Formato: PDF


Thumbnail

Este ítem aparece na(s) seguinte(s) colección(s)

Mostrar o rexistro simple do ítem

© 2022 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH  This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
A licenza do ítem descríbese como
 © 2022 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited





Recolectores:Enlaces de interese:
Universidade de Santiago de Compostela | Teléfonos: +34 881 811 000 e +34 982 820 000 | Contacto | Suxestións