• Aggregation versus inclusion complexes to solubilize drugs with cyclodextrins. A case study using sulphobutylether-β-cyclodextrins and remdesivir 

  Piñeiro Guillén, Ángel; García Fandiño, Rebeca; PIPKIN, JAMES; Antle, Vince (Elsevier, 2021)

  The formation of small hybrid aggregates between excipient and drug molecules is one of the mechanisms that contributes to the solubilization of active principles in pharmaceutical formulations. The characterization of the ...

• Remdesivir interactions with sulphobutylether-β-cyclodextrins: a case study using selected substitution patterns 

  Piñeiro Guillén, Ángel; Pipkin, James; Antle, Vince; García Fandiño, Rebeca (Elsevier, 2022)

  Modified cyclodextrins (CDs) consist of a distribution of different structures with different number and location of the substituted groups. Among the most important applications of these molecules is their use as an ...

• Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage 

  Rodríguez Villar, Jéssica; Pérez González, Cibrán; Martínez Calvo, Miguel; Mosquera Mosquera, Jesús; Mascareñas Cid, José Luis (Royal Society of Chemistry, 2022)

  Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric ...

• (4 + 2) Cycloadditions via Pd C(sp3 )–H activation 

  Vidal Pereira, Xandro; Font Molíns, Marc; Cendón Mariño, Borja; Mascareñas Cid, José Luis; Gulías Costa, Moisés (Elsevier, 2021)

  The functionalization of aliphatic C (sp3)-H bonds using Pd catalysis has emerged as a powerful, step economical methodology for the construction of C–C and C–X bonds. Despite the progress in this field, examples of formal ...

• Pd-Catalyzed Allylic C-H Activation to Seven-Membered N,O-Heterocycles 

  Velasco Rubio, Álvaro; Varela Carrete, Jesús Ángel; Saá Rodríguez, Carlos (Royal Society of Chemistry, 2021)

  Pd-catalyzed allylic C-H activation of simple olefins allows an easy entry to seven-membered N,O-heterocycles such as 1,4-benzoxazepines (1,4-BZOs), 1,4-benzodiazepinones (1,4-BZDs) and 1,4-oxazepanes in good to excellent ...

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