Recent Submissions

  • Trending Topics on Coumarin and Its Derivatives in 2020 

    Carneiro Viqueira, Aitor; Matos, Maria João Correia Pinto Carvalho de; Uriarte Villares, Eugenio; Santana Penín, María Lourdes (MDPI, 2021)
    Coumarins are naturally occurring molecules with a versatile range of activities. Their structural and physicochemical characteristics make them a privileged scaffold in medicinal chemistry and chemical biology. Many ...
  • Chemical and biological analysis of 4-acyloxy-3-nitrocoumarins as trypanocidal agents 

    Salgado, Francisco J.; Moncada Basualto, Mauricio; Pozo Martínez, Josué; Liempi, Ana; Kemmerling, Ulrike; Maya, Juan Diego; Jaque, Pablo; Borges, Fernanda; Uriarte Villares, Eugenio; Matos, Maria João Correia Pinto Carvalho de; Olea Azar, Claudio (Elsevier, 2021)
    Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. ...
  • Indium-mediated allylation and Reformatsky reaction on glyoxylic oximes under ultrasound irradiation 

    González Soengas, Raquel María; Estévez Reino, Amalia María (Elsevier, 2012)
    A novel and more convenient method for the indium-promoted allylation of glyoxylic oximes based on the use of ultrasonic waves is reported. A similar procedure was used to develop the first example reported in the literature ...
  • Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins 

    Matos, Maria João Correia Pinto Carvalho de; Pérez Cruz, Fernanda; Vázquez Rodríguez, Saleta; Uriarte Villares, Eugenio; Santana Penín, María Lourdes; Borges, Fernanda; Olea Azar, Claudio (Elsevier, 2013)
    In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical ...
  • QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes 

    Lence Quintana, Emilio José; der Kamp, Marc W. van; González Bello, Concepción; Mulholland, Adrian J. (Royal Society of Chemistry, 2018)
    Type II dehydroquinase enzymes (DHQ2), recognized targets for antibiotic drug discovery, show significantly different activities dependent on the species: DHQ2 from Mycobacterium tuberculosis (MtDHQ2) and Helicobacter ...

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