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dc.contributor.author | González Durruthy, Michael |
dc.contributor.author | Rial Silva, Ramón |
dc.contributor.author | Liu, Zhen |
dc.contributor.author | Ruso Veiras, Juan Manuel |
dc.date.accessioned | 2022-11-10T08:43:55Z |
dc.date.available | 2022-11-10T08:43:55Z |
dc.date.issued | 2022 |
dc.identifier.citation | Journal of Molecular Liquids 366 (2022) 120370. https://doi.org/10.1016/j.molliq.2022.120370 |
dc.identifier.uri | http://hdl.handle.net/10347/29401 |
dc.description.abstract | Effective and reliable prediction of allosteric molecular interactions involved in protein-ligand systems are essential to understand pharmacological modulation and toxicology processes that are driven by multiple factors covering from the atomistic to cellular level. Even though the interactions taking place within a defined biophysical environment are usually intricate and complex, having a preliminary knowledge of the structural determinant and biochemical function of target enzyme in the physiological or unbound state represent a step forward in the characterization of the forces involved these processes under interaction conditions as induced by drugs. In the present work, we tackle the study of relevant binding interactions between two well-recognized betablocker drugs and the lysozyme biological target from an experimental-computational perspective. In this way, molecular docking, machine learning and perturbation analysis combined with UV–vis and fluorescence measurements will allow us to determine the allosteric regulation and functional dynamics of lysozyme by binding propranolol and acebutolol |
dc.description.sponsorship | The authors acknowledge Ministerio de Ciencia e Innovación (PID2019-111327GB-100) |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.rights | © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject | Betablocker drugs |
dc.subject | Lysozyme |
dc.subject | Allosteric interactions |
dc.subject | Molecular docking |
dc.title | Lysozyme allosteric interactions with β-blocker drugs |
dc.type | journal article |
dc.relation.publisherversion | https://doi.org/10.1016/j.molliq.2022.120370 |
dc.type.hasVersion | VoR |
dc.identifier.essn | 0167-7322 |
dc.rights.accessRights | open access |
dc.contributor.affiliation | Universidade de Santiago de Compostela. Departamento de Física Aplicada |
dc.description.peerreviewed | SI |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111327GB-100/ES/DISEÑO DE NANOBOTS DE CONTROL SENCILLO BASADOS EN AUTOENSAMBLAJE MOLECULAR ESPONTANEO |
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