Therapeutic alternatives for the treatment of ocular inflammatory diseases
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| Title: | Therapeutic alternatives for the treatment of ocular inflammatory diseases |
| Author: | García Otero, Xurxo |
| Advisor: | Otero Espinar, Francisco Javier Fernández Ferreiro, Anxo Aguiar Fernández, Pablo |
| Affiliation: | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación e Desenvolvemento de Medicamentos |
| Subject: | ocular inflammatory diseases | tacrolimus | adalimumab | pharmacokinetics | drug delivery | |
| Date of Issue: | 2022 |
| Abstract: | In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems. |
| URI: | http://hdl.handle.net/10347/29914 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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- Área de Ciencias da Saúde [1158]
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional