Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages
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| Title: | Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages |
| Author: | Fernández Mariño, Iago Anfray, Clément Crecente Campo, José Maeda, Akihiro Ummarino, Aldo Teijeiro Valiño, Carmen Blanco Martínez, Darío Mpambani, Francis Poul, Laurence Devalliere, Julie Germain, Matthieu Correa Chinea, Juan Francisco Fernández Villamarín, Marcos Allavena, Paola Fernández Megía, Eduardo Alonso Fernández, María José Torres Andón, Fernando |
| Affiliation: | Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica Universidade de Santiago de Compostela. Departamento de Química Orgánica |
| Subject: | Cancer | Hyaluronic acid | Mannose | Polymeric nanocapsules | Nanoprimer | Tumor-associated macrophages | |
| Date of Issue: | 2022 |
| Publisher: | Springer |
| Citation: | Fernández-Mariño, I., Anfray, C., Crecente-Campo, J. et al. Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages. Drug Deliv. and Transl. Res. (2022). https://doi.org/10.1007/s13346-022-01265-9 |
| Abstract: | Tumor-associated macrophages (TAMs), a class of immune cells that play a key role in tumor immunosuppression, are recognized as important targets to improve cancer prognosis and treatment. Consequently, the engineering of drug delivery nanocarriers that can reach TAMs has acquired special relevance. This work describes the development and biological evaluation of a panel of hyaluronic acid (HA) nanocapsules (NCs), with different compositions and prepared by different techniques, designed to target macrophages. The results showed that plain HA NCs did not significantly influence the polarization of M0 and M2-like macrophages towards an M1-like pro-inflammatory phenotype; however, the chemical functionalization of HA with mannose (HA-Man) led to a significant increase of NCs uptake by M2 macrophages in vitro and to an improved biodistribution in a MN/MNCA1 fibrosarcoma mouse model with high infiltration of TAMs. These functionalized HA-Man NCs showed a higher accumulation in the tumor compared to non-modified HA NCs. Finally, the pre-administration of the liposomal liver occupying agent Nanoprimer™ further increased the accumulation of the HA-Man NCs in the tumor. This work highlights the promise shown by the HA-Man NCs to target TAMs and thus provides new options for the development of nanomedicine and immunotherapy-based cancer treatments |
| Publisher version: | https://doi.org/10.1007/s13346-022-01265-9 |
| URI: | http://hdl.handle.net/10347/30000 |
| DOI: | 10.1007/s13346-022-01265-9 |
| ISSN: | 2190-393X |
| E-ISSN: | 2190-3948 |
| Rights: | © 2022 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ Atribución 4.0 Internacional |
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Except where otherwise noted, this item's license is described as © 2022 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/