• ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents 

  Barja Fernández, Silvia; Folgueira Cobos, Cintia; Castelao Taboada, Cecilia; Pena León, Verónica; González Saenz, Patricia; Vázquez Cobela, Rocío; Aguilera, Concepción M.; Gil Campos, Mercedes; Bueno Lozano, Gloria; Gil, Ángel; Moreno, Luis A.; Ruiz Piñón, Manuel; García Palacios, María; Casanueva Freijo, Felipe; Diéguez González, Carlos; Nogueiras Pozo, Rubén; Leis Trabazo, María Rosaura; Seoane Camino, Luisa María (MDPI, 2019)

  Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its ...

• Design of Polymeric Nanocapsules for Intranasal Vaccination against Mycobacterium Tuberculosis: Influence of the Polymeric Shell and Antigen Positioning 

  Diego González, Lara; Crecente Campo, José; Paul, Matthew John; Singh, Mahavir; Reljic, Rajko; Alonso Fernández, María José; González Fernández, África; Simón Vázquez, Rosana (MDPI, 2020)

  Tuberculosis (TB) is the leading cause of death from a single infectious microorganism and Bacillus Calmette Guerin (BCG), the only authorized vaccine, does not confer protection against pulmonary TB. Based on the hypothesis ...

• PARP1 Deficiency Reduces Tumour Growth by Decreasing E2F1 Hyperactivation: A Novel Mechanism in the Treatment of Cancer 

  Iglesias, Pablo; Seoane Souto, Marcos; Golán Cancela, Irene; Castro Piedras, Isabel; Fraga Rodríguez, Máximo Francisco; Arce Vázquez, Víctor Manuel; Costoya Puente, José Antonio (MDPI, 2020)

  In recent years, poly (ADP-ribose) polymerase (PARP) inhibitors have been evaluated for treating homologous recombination-deficient tumours, taking advantage of synthetic lethality. However, increasing evidence indicates ...

• Engineering Anisotropic Meniscus: Zonal Functionality and Spatiotemporal Drug Delivery 

  Abbadessa, Anna; Crecente Campo, José; Alonso Fernández, María José (Mary Ann Liebert, 2020)

  Human meniscus is a fibrocartilaginous structure that is crucial for an adequate performance of the human knee joint. Degeneration of the meniscus is often followed by partial or total meniscectomy, which enhances the risk ...

• New Morphiceptin Peptidomimetic Incorporating (1S,2R,3S,4S,5R)-2-Amino-3,4,5-trihydroxycyclopen-tane-1-carboxylic acid: Synthesis and Structural Study 

  González Soengas, Raquel María; Lorca Carvajal, Marcos Antonio; Pampín Casal, María Begoña; Sánchez Pedregal, Víctor Manuel; Estévez Cabanas, Ramón José; Estévez Cabanas, Juan Carlos (MDPI, 2020)

  We present the synthesis and structural study of a new peptidomimetic of morphiceptin, which can formally be considered as the result of the replacement of the central proline residue of this natural analgesic drug with a ...

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