Recent Submissions

  • Silver clusters of five atoms as highly selective antitumoral agents through irreversible oxidation of thiols 

    Porto González, Vanesa; Buceta Fernández, David; Domínguez Loidi, Blanca; Carneiro Freire, María del Carmen; Borrajo Alonso, Erea; Fraile Piñeiro, María; Davila Ferreira, Nerea; Rodríguez Arias, Iria; Blanco Trillo, José Manuel; Blanco Varela, María del Carmen; Devida, Juan Marcelo; Giovanetti, Lisandro José; Requejo, Félix Gregorio; Hernández Garrido, Juan Carlos; Calvino Gámez, José Juan; López Haro, Miguel; Barone, Giampaolo; James, Andrew M.; García-Caballero Parada, Tomás; González Castaño, Diego Miguel; Treder, Martin; Huber, Wolfgang; Vidal Figueroa, Anxo; Michael, P. Murphy; López Quintela, Manuel Arturo; Domínguez Puente, Fernando Ignacio (Wiley, 2022)
    Low atomicity clusters present properties dependent on the size, due to the quantum confinement, with well-defined electronic structures and high stability. Here it is shown that Ag5 clusters catalyze the complete oxidation ...
  • Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3 Antagonists 

    Miranda Pastoriza, Darío; Bernárdez Alfaya, Rodrigo; Azuaje Guerrero, Jhonny Alberto; Prieto Díaz, Rubén; Majellaro, Maria; Tamhankar, Ashish V.; Koenekoop, Lucien; González García, Alejandro; Gioé Gallo, Claudia; Mallo-Abreu, Ana; Brea Floriani, José Manuel; Loza García, María Isabel; García Rey, Aitor; García Mera, Xerardo Xusto; Gutiérrez de Terán, Hugo; Sotelo, Eddy (ACS Publications, 2022)
    A library of potent and highly A3AR selective pyrimidine-based compounds was designed to explore non-orthosteric interactions within this receptor. Starting from a prototypical orthosteric A3AR antagonist (ISVY130), the ...
  • Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists 

    Val García, Cristina; Rodríguez García, Carlos; Prieto Díaz, Rubén; Crespo Gavilán, Abel; Azuaje Guerrero, Jhonny Alberto; Carbajales Pérez, Carlos; Majellaro, María; Díaz Holguín, Alejandro; Brea Floriani, José Manuel; Loza García, María Isabel; Gioé Gallo, Claudia; Contino, Marialessandra; Stefanachi, Angela; García Mera, Xerardo Xusto; Estévez Cabanas, Juan Carlos; Gutiérrez de Terán, Hugo; Sotelo, Eddy (ACS Publications, 2022)
    We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A1AR ligands. The most attractive ligands were confirmed as antagonists of ...
  • Study of plasma anti-CD26 autoantibody levels in a cohort of treatment-naïve early arthritis patients 

    Cordero Santamaría, Óscar Javier; Viéitez González, Irene; Altabás González, Irene; Nuño Nuño, Laura; Villalba Yllán, Alejandro; Novella Navarro , Marta; Peiteado López, Diana; Miranda-Carús, María-Eugenia; Balsa Criado, Alejandro; Varela Calviño, Rubén; Gómez Touriño, Iria María; Pego Reigosa, José María (Springer, 2022)
    In rheumatoid arthritis (RA), the identifcation of biomarkers to adjust treatment intensity and to correctly diagnose the disease in early stages still constitutes a challenge and, as such, novel biomarkers are needed. We ...
  • Activation of hypothalamic AMP-activated protein kinase ameliorates metabolic complications of experimental arthritis 

    Seoane Collazo, Patricia; Rial Pensado, Eva; Estévez Salguero, Ánxela María; Milbank, Edward; García Caballero, Lucía; Ríos García, Marcos; Liñares Pose, Laura; Scotece, Morena; Gallego Gómez, María Rosalía; Fernández-Real, Jose Manuel; Nogueiras Pozo, Rubén; Diéguez González, Carlos; Gualillo, Oreste; López Pérez, Miguel Antonio (Wiley, 2021)
    Objective: To investigate whether thermogenesis and the hypothalamus may be involved in the physiopathology of experimental arthritis (EA). Methods: EA was induced in male Lewis rats by intradermal injection of Freund's ...

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