Now showing items 1-20 of 125

    • 26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines 

      Seoane Ruzo, Samuel; Álvarez Bermúdez, María José; Sendón Lago, Juan José; Martínez Ordóñez, Anxo; Abdul-Hadi, Soraya; Maestro Saavedra, Miguel Anxo; Mouriño Mosquera, Antonio; Pérez Fernández, Román (MDPI, 2013)
      It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ...
    • 5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines 

      Toro Sazo, Miguel; Brea Floriani, José Manuel; Loza García, María Isabel; Cimadevila Fondevila, Marta; Cassels, Bruce K. (PLOS, 2019)
      The last fifteen years have seen the emergence and overflow into the drug scene of “superpotent” N-benzylated phenethylamines belonging to the “NBOMe” series, accompanied by numerous research articles. Although N-benzyl ...
    • 8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects 

      Pilar Olaya, María del; Vergel, Nadezdha Esperanza; López, Jose Luis; Viña Castelao, María Dolores (Universidade de São Paulo, 2020)
      Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new ...
    • Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging 

      Vilas Martínez, Jéssica María; Carneiro Freire, María del Carmen; Silva Álvarez, Sabela da; Ferreirós López, Alba; González, Patricia; Gómez, María; Ortega, Sagrario; Serrano, Manuel; García-Caballero Parada, Tomás; González Barcia, Luis Miguel; Vidal Figueroa, Anxo; Collado, Manuel (Wiley, 2018-08-20)
      Aging is characterized by a gradual functional decline of tissues with age. Adult stem and progenitor cells are responsible for tissue maintenance, repair, and regeneration, but during aging, this population of cells is ...
    • Advances on the formulation of proteins using nanotechnologies 

      Santalices Ramos, Irene; Gonella, Andrea; Torres López, María Dolores Ramona; Alonso Fernández, María José (Elsevier, 2017-12)
      Therapeutic proteins and peptides are very attractive from the pharmaceutical point of view due to their high potency and selectivity. Nonetheless, their instability and low bioavailability make their adminis- tration ...
    • Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches 

      Vélez, Paula; Ocaranza-Sanchez, Raymundo; López-Otero, Diego; Grigorian Shamagian, Lilian; Rosa, Isaac; Guitián Fernández, Esteban; García Acuña, José María; González Juanatey, José Ramón; García, Ángel (Nature Publishing Group, 2016-12-22)
      The platelet-specific collagen receptor glycoprotein VI (GPVI) is critical for the formation of arterial thrombosis in vivo. We analyzed GPVI-activated platelets from ST-elevation myocardial infarction (STEMI) patients and ...
    • Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning 

      Pellegrini, Camilla; Columbaro, Marta; Schena, Elisa; Prencipe, Sabino; Andrenacci, Davide; Iozzo, Patricia; Guzzardi, Maria Angela; Capanni, Cristina; Mattioli, Elisabetta; Loi, Manuela; Araújo Vilar, David; Squarzoni, Stefano; Cinti, Saverio; Morselli, Paolo; Giorgetti, Assuero; Zanotti, Laura; Gambineri, Alessandra; Lattanzi, Giovanna (2019-08-02)
      Type-2 Familial Partial Lipodystrophy is caused by LMNA mutations. Patients gradually lose subcutaneous fat from the limbs, while they accumulate adipose tissue in the face and neck. Several studies have demonstrated that ...
    • An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures 

      Collord, Grace; Tarpey, Patrick; Kurbatova, Natalja; Martincorena, Inigo; Morán, Sebastián; Castro, Manuel; Nagy, Tibor; Bignell, Graham; Maura, Francesco; Young, Matthew D.; Berna, Jorge; Castro Tubío, José Manuel; McMurran, Chris E.; Young, Adam M.H.; Sanders, Mathijs; Noorani, Imran; Price, Stephen J.; Watts, Colin; Leipnitz, Elke; Kirsch, Matthias; Schackert, Gabriele; Pearson, Danita; Devadass, Abel; Ram, Zvi; Collins, V. Peter; Allinson, Kieren; Jenkinson, Michael D.; Zakaria, Rasheed; Syed, Khaja; Hanemann, C. Oliver; Dunn, Jemma; McDermott, Michael W.; Kirollos, Ramez W.; Vassiliou, George S.; Esteller, Manel; Behjati, Sam; Brazma, Alvis; Santarius, Thomas; McDermott, Ultan (Nature Publishing Group, 2018)
      Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles ...
    • Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain 

      Couselo Carreira, Marcos; Andrade, Sara María Monteiro Sousa; González Izquierdo, Andrea; Amil Diz, María; Folgueira Cobos, Cintia; Crujeiras Martínez, Ana Belén; Casanueva Freijo, Felipe (Nature Publishing Group, 2018)
      The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with ...
    • A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain 

      Iglesias, Pablo; Penas Tallón, Cristina; Barral Cagiao, Laura; Pazos Chantrero, Elena; Costoya Puente, José Antonio (Nature Publishing Group, 2019)
      Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. ...
    • Biomaterials to suppress cancer stem cells and disrupt their tumoral niche 

      Garcia-Mazas, Carla; Csaba, Noemi; García-Fuentes, Marcos (Elsevier, 2017-05-25)
      Lack of improvement in the treatment options of several types of cancer can largely be attributed to the presence of a subpopulation of cancer cells with stem cell signatures and to the tumoral niche that supports and ...
    • Cell senescence is an antiviral defense mechanism 

      Baz-Martínez, Maite; Silva Álvarez, Sabela da; Rodríguez, Estefanía; Guerra Varela, Jorge; El Motiam, Ahmed; Vidal Figueroa, Anxo; García-Caballero Parada, Tomás; González Barcia, Miguel; Sánchez Piñón, Laura; Muñoz Fontela, Cesar; Collado, Manuel; Rivas Vázquez, Carmen (Nature Publishing Group, 2016)
      Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell ...
    • Central nicotine induces browning through hypothalamic κ opioid receptor 

      Seoane Collazo, Patricia; Liñares Pose, Laura; Rial Pensado, Eva; Romero Picó, Amparo; Moreno Navarrete, José María; Martínez Sánchez, Noelia; Garrido Gil, Pablo; Iglesias Rey, Ramón; Morgan, Donald A.; Tomasini, Naoki; Malone, Samuel Andrew; Senra, Ana; Folgueira Cobos, Cintia; Medina Gómez, Gema; Sobrino Moreiras, Tomás; Labandeira García, José Luis; Nogueiras Pozo, Rubén; Domingos, Ana I.; Fernández Real, José Manuel; Rahmouni, Kamal; Diéguez González, Carlos; López Pérez, Miguel Antonio (Nature Publishing Group, 2019)
      [ENG]Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both ...
    • Central nicotine induces browning through hypothalamic κ opioid receptor 

      Seoane Collazo, Patricia; Liñares Pose, Laura; Rial Pensado, Eva; Romero Picó, Amparo; Moreno Navarrete, José María; Martínez Sánchez, Noelia; Garrido Gil, Pablo; Iglesias Rey, Ramón; Morgan, Donald A.; Tomasini, Naoki; Malone, Samuel Andrew; Senra, Ana; Folgueira Cobos, Cintia; Medina Gómez, Gema; Sobrino Moreiras, Tomás; Labandeira García, José Luis; Nogueiras Pozo, Rubén; Domingos, Ana I.; Fernández Real, José Manuel; Rahmouni, Kamal; Diéguez González, Carlos; López Pérez, Miguel Antonio (Nature Publishing Group, 2019)
      [ENG]Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding ...
    • Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis 

      Petljak, Mia; Alexandrov, Ludmil B.; Brammeld, Jonathan S.; Price, Stacey; Wedge, David C.; Grossmann, Sebastian; Dawson, Kevin J.; Ju, Young Seok; Ioro, Francesco; Castro Tubío, José Manuel; Koh, Ching Chiek; Georgakopoulos Soares, Ilias; Rodríguez Martín, Bernardo; Otlu, Burçak; O'Meara, Sarah; Butler, Adam P.; Menzies, Andrew; Bhosle, Shriram G.; Raine, Keiran; Jones, David R.; Teague, Jon W.; Beal, Kathryn; Latimer, Calli; O'Neill, Laura; Zamora Berna, Jorge Aurelio; Anderson, Elizabeth; Patel, Nikita; Maddison, Mark; Ng, Bee Ling; Graham, Jennifer; Garnett, Mathew J.; McDermott, Ultan; Nik Zainal, Serena; Campbell, Peter J.; Stratton, Michael R. (Elsevier, 2019)
      Multiple signatures of somatic mutations have beenidentified in cancer genomes. Exome sequences of1,001 human cancer cell lines and 577 xenograftsrevealed most common mutational signatures,indicating past activity of ...
    • Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers 

      Hidalgo, T.; Giménez Marqués, M.; Bellido, E.; Avila, J.; Asensio, M.C.; Salles, F.; Lozano, M.V.; Guillevic, M.; Simón Vázquez, Rosana; González Fernández, África; Serre, C.; Alonso Fernández, María José; Horcajada, P. (Springer Nature, 2017)
      Nanometric biocompatible Metal-Organic Frameworks (nanoMOFs) are promising candidates for drug delivery. Up to now, most studies have targeted the intravenous route, related to pain and severe complications; whereas nanoMOFs ...
    • Chitosan-Poly (I:C)-PADRE Based Nanoparticles as Delivery Vehicles for Synthetic Peptide Vaccines 

      Correia Pinto, Jorge F.; Csaba, Noemi Stefania; Schiller, John T.; Alonso Fernández, María José (MDPI, 2015)
      The safety and precision of peptide antigens has prompted the search for adjuvants capable of increasing the immune response against these intrinsically poorly immunogenic antigens. The integration of both immunostimulants ...
    • Circulating irisin levels are not regulated by nutritional status, obesity, or leptin levels in rodents 

      Quiñones Téllez, María del Mar; Folgueira Cobos, Cintia; Sánchez Rebordelo, María Estrella; Al-Massadi Iglesias, Omar (Hindawi, 2015)
      Irisin is a cleaved and secreted fragment of fibronectin type III domain containing 5 (FNDC5) that is mainly released by skeletal muscle and was proposed to mediate the beneficial effects of exercise on metabolism. In the ...
    • Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model 

      Gómez-Mauricio, Guadalupe; Moscoso, Isabel; Martín-Cancho, María-Fernanda; Crisóstomo, Verónica; Prat-Vidal, Cristina; Báez Díaz, Claudia; Sánchez-Margallo, Francisco M.; Bernad, Antonio (BioMed Central, 2016-07-16)
      Background Insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) are among the most promising growth factors for promoting cardiorepair. Here, we evaluated the combination of cell- and gene-based therapy ...
    • A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade 

      Izquierdo Berjano, Irene; Núñez Barrachina, María; Hermida Nogueira, Lidia; Casas, Vanessa; Morán Lara, Luis Arturo; Lacerenza, Serena; Pinto-Llorente, Roberto; Eble, Johannes A.; Ríos, Vivian de los; Domínguez Medina, Eduardo; Loza García, María Isabel; Casal, José Ignacio; Carrascal, Montserrat; Abián, Joaquín; García Alonso, Ángel (Thieme Publishing Group, 2020)
      C-type lectin-like receptor 2 (CLEC-2) plays a crucial role in different platelet-related physiological and pathological processes. It signals through a tyrosine kinase-mediated pathway that is highly dependent on the ...





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