Now showing items 1-20 of 196

    • 26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines 

      Seoane Ruzo, Samuel; Álvarez Bermúdez, María José; Sendón Lago, Juan José; Martínez Ordóñez, Anxo; Abdul-Hadi, Soraya; Maestro Saavedra, Miguel Anxo; Mouriño Mosquera, Antonio; Pérez Fernández, Román (MDPI, 2013)
      It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ...
    • 5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines 

      Toro Sazo, Miguel; Brea Floriani, José Manuel; Loza García, María Isabel; Cimadevila Fondevila, Marta; Cassels, Bruce K. (PLOS, 2019)
      The last fifteen years have seen the emergence and overflow into the drug scene of “superpotent” N-benzylated phenethylamines belonging to the “NBOMe” series, accompanied by numerous research articles. Although N-benzyl ...
    • 8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects 

      Pilar Olaya, María del; Vergel, Nadezdha Esperanza; López, Jose Luis; Viña Castelao, María Dolores (Universidade de São Paulo, 2020)
      Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new ...
    • Activation of hypothalamic AMP-activated protein kinase ameliorates metabolic complications of experimental arthritis 

      Seoane Collazo, Patricia; Rial Pensado, Eva; Estévez Salguero, Ánxela María; Milbank, Edward; García Caballero, Lucía; Ríos García, Marcos; Liñares Pose, Laura; Scotece, Morena; Gallego Gómez, María Rosalía; Fernández-Real, Jose Manuel; Nogueiras Pozo, Rubén; Diéguez González, Carlos; Gualillo, Oreste; López Pérez, Miguel Antonio (Wiley, 2021)
      Objective: To investigate whether thermogenesis and the hypothalamus may be involved in the physiopathology of experimental arthritis (EA). Methods: EA was induced in male Lewis rats by intradermal injection of Freund's ...
    • Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging 

      Vilas Martínez, Jéssica María; Carneiro Freire, María del Carmen; Silva Álvarez, Sabela da; Ferreirós López, Alba; González, Patricia; Gómez, María; Ortega, Sagrario; Serrano, Manuel; García-Caballero Parada, Tomás; González Barcia, Luis Miguel; Vidal Figueroa, Anxo; Collado, Manuel (Wiley, 2018-08-20)
      Aging is characterized by a gradual functional decline of tissues with age. Adult stem and progenitor cells are responsible for tissue maintenance, repair, and regeneration, but during aging, this population of cells is ...
    • Advances on the formulation of proteins using nanotechnologies 

      Santalices Ramos, Irene; Gonella, Andrea; Torres López, María Dolores Ramona; Alonso Fernández, María José (Elsevier, 2017-12)
      Therapeutic proteins and peptides are very attractive from the pharmaceutical point of view due to their high potency and selectivity. Nonetheless, their instability and low bioavailability make their adminis- tration ...
    • Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches 

      Vélez, Paula; Ocaranza-Sanchez, Raymundo; López-Otero, Diego; Grigorian Shamagian, Lilian; Rosa, Isaac; Guitián Fernández, Esteban; García Acuña, José María; González Juanatey, José Ramón; García, Ángel (Nature Publishing Group, 2016-12-22)
      The platelet-specific collagen receptor glycoprotein VI (GPVI) is critical for the formation of arterial thrombosis in vivo. We analyzed GPVI-activated platelets from ST-elevation myocardial infarction (STEMI) patients and ...
    • Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning 

      Pellegrini, Camilla; Columbaro, Marta; Schena, Elisa; Prencipe, Sabino; Andrenacci, Davide; Iozzo, Patricia; Guzzardi, Maria Angela; Capanni, Cristina; Mattioli, Elisabetta; Loi, Manuela; Araújo Vilar, David; Squarzoni, Stefano; Cinti, Saverio; Morselli, Paolo; Giorgetti, Assuero; Zanotti, Laura; Gambineri, Alessandra; Lattanzi, Giovanna (2019-08-02)
      Type-2 Familial Partial Lipodystrophy is caused by LMNA mutations. Patients gradually lose subcutaneous fat from the limbs, while they accumulate adipose tissue in the face and neck. Several studies have demonstrated that ...
    • An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures 

      Collord, Grace; Tarpey, Patrick; Kurbatova, Natalja; Martincorena, Inigo; Morán, Sebastián; Castro, Manuel; Nagy, Tibor; Bignell, Graham; Maura, Francesco; Young, Matthew D.; Berna, Jorge; Castro Tubío, José Manuel; McMurran, Chris E.; Young, Adam M.H.; Sanders, Mathijs; Noorani, Imran; Price, Stephen J.; Watts, Colin; Leipnitz, Elke; Kirsch, Matthias; Schackert, Gabriele; Pearson, Danita; Devadass, Abel; Ram, Zvi; Collins, V. Peter; Allinson, Kieren; Jenkinson, Michael D.; Zakaria, Rasheed; Syed, Khaja; Hanemann, C. Oliver; Dunn, Jemma; McDermott, Michael W.; Kirollos, Ramez W.; Vassiliou, George S.; Esteller, Manel; Behjati, Sam; Brazma, Alvis; Santarius, Thomas; McDermott, Ultan (Nature Publishing Group, 2018)
      Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles ...
    • ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents 

      Barja Fernández, Silvia; Folgueira Cobos, Cintia; Castelao Taboada, Cecilia; Pena León, Verónica; González Saenz, Patricia; Vázquez Cobela, Rocío; Aguilera, Concepción M.; Gil Campos, Mercedes; Bueno Lozano, Gloria; Gil, Ángel; Moreno, Luis A.; Ruiz Piñón, Manuel; García Palacios, María; Casanueva Freijo, Felipe; Diéguez González, Carlos; Nogueiras Pozo, Rubén; Leis Trabazo, María Rosaura; Seoane Camino, Luisa María (MDPI, 2019)
      Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its ...
    • Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain 

      Couselo Carreira, Marcos; Andrade, Sara María Monteiro Sousa; González Izquierdo, Andrea; Amil Diz, María; Folgueira Cobos, Cintia; Crujeiras Martínez, Ana Belén; Casanueva Freijo, Felipe (Nature Publishing Group, 2018)
      The incidence of obesity has been increasing dramatically worldwide over the past decades, thus requiring novel and effective therapeutic approaches. OBEX is an oral nutritional supplement composed of antioxidants with ...
    • Astrocyte Clocks and Glucose Homeostasis 

      Barca Mayo, Olga; López Pérez, Miguel Antonio (Frontiers Media, 2021)
      The endogenous timekeeping system evolved to anticipate the time of the day through the 24 hours cycle of the Earth’s rotation. In mammals, the circadian clock governs rhythmic physiological and behavioral processes, ...
    • Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19 

      Rodríguez Pérez, Ana Isabel; Labandeira, Carmen M.; Pedrosa Sánchez, María Ángeles; Valenzuela Limiñana, Rita; Suárez Quintanilla, Juan Antonio; Cortes Ayaso, María; Mayán Conesa, Plácido; Labandeira García, José Luis (Elsevier, 2021)
      The renin-angiotensin system (RAS) plays a major role in COVID-19. Severity of several inflammation-related diseases has been associated with autoantibodies against RAS, particularly agonistic autoantibodies for angiotensin ...
    • A bio-inspired hypoxia sensor using HIF1a-oxygen-dependent degradation domain 

      Iglesias, Pablo; Penas Tallón, Cristina; Barral Cagiao, Laura; Pazos Chantrero, Elena; Costoya Puente, José Antonio (Nature Publishing Group, 2019)
      Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. ...
    • Bioelectronics-on-a-chip for cardio myoblast proliferation enhancement using electric field stimulation 

      Aragón Beloso, Angel Luis; Cebro Márquez, María; Pérez Trigo, Eliseo; Pazos Álvarez, Antonio; Lage Fernández, Ricardo; González Juanatey, José Ramón; Moscoso Galán, Isabel; Bao Varela, María del Carmen; Nieto García, Daniel (Springer Nature, 2020)
      Background: Cardio myoblast generation from conventional approaches is laborious and time-consuming. We present a bioelectronics on-a-chip for stimulating cells cardio myoblast proliferation during culture. Method: The ...
    • Biomaterials to suppress cancer stem cells and disrupt their tumoral niche 

      Garcia-Mazas, Carla; Csaba, Noemi; García-Fuentes, Marcos (Elsevier, 2017-05-25)
      Lack of improvement in the treatment options of several types of cancer can largely be attributed to the presence of a subpopulation of cancer cells with stem cell signatures and to the tumoral niche that supports and ...
    • Caloric Restriction Prevents Metabolic Dysfunction and the Changes in Hypothalamic Neuropeptides Associated with Obesity Independently of Dietary Fat Content in Rats 

      Martín, Marina; Rodríguez, Amaia; Gómez Ambrosi, Javier; Ramírez, Beatriz; Becerril, Sara; Catalán, Victoria; López Pérez, Miguel Antonio; Diéguez González, Carlos; Frühbeck, Gema; Burrell, María Ángela (MDPI, 2021)
      Energy restriction is a first therapy in the treatment of obesity, but the underlying biological mechanisms have not been completely clarified. We analyzed the effects of restriction of high-fat diet (HFD) on weight loss, ...
    • Celia’s Encephalopathy (BSCL2-Gene-Related): Current Understanding 

      Sánchez Iglesias, Sofía; Fernández Pombo, Antía; Cobelo Gómez, Silvia; Hermida Ameijeiras, Álvaro; Alarcón Martínez, Helena; Domingo Jiménez, María Rosario; Ruiz Riquelme, Alejandro Iván; Rodríguez Requena, Jesús; Araújo Vilar, David (MDPI, 2021)
      Seipin, encoded by the BSCL2 gene, is a protein that in humans is expressed mainly in the central nervous system. Uniquely, certain variants in BSCL2 can cause both generalized congenital lipodystrophy type 2, upper and/or ...
    • Cell senescence is an antiviral defense mechanism 

      Baz-Martínez, Maite; Silva Álvarez, Sabela da; Rodríguez, Estefanía; Guerra Varela, Jorge; El Motiam, Ahmed; Vidal Figueroa, Anxo; García-Caballero Parada, Tomás; González Barcia, Miguel; Sánchez Piñón, Laura; Muñoz Fontela, Cesar; Collado, Manuel; Rivas Vázquez, Carmen (Nature Publishing Group, 2016)
      Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell ...
    • Cellular and Molecular Mechanisms Underlying Glioblastoma and Zebrafish Models for the Discovery of New Treatments 

      Reimunde Figueira, Pedro Marcos; Pensado López, Alba; Carreira Crende, Martín; Lombao Iglesias, Vanesa; Sánchez Piñón, Laura Elena; Torrecilla Parra, Marta; Ramírez, Cristina M.; Anfray, Clément; Torres Andón, Fernando (MDPI, 2021)
      Glioblastoma (GBM) is the most common of all brain malignant tumors; it displays a median survival of 14.6 months with current complete standard treatment. High heterogeneity, aggressive and invasive behavior, the impossibility ...





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