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Glucagon, GLP-1 and thermogenesis

González García, Ismael; Milbank, Edward; Diéguez González, Carlos; López Pérez, Miguel Antonio; Contreras, Cristina (MDPI, 2019)

Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, ...

Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake

Liñares Pose, Laura; Rial Pensado, Eva; Estévez Salguero, María Ánxela; Milbank, Edward; González García, Ismael; Rodríguez, Claudia; Seoane Collazo, Patricia; Martínez Sánchez, Noelia; Nogueiras Pozo, Rubén; Prieto, Dolores; Diéguez González, Carlos; Contreras, Cristina; López Pérez, Miguel Antonio (MDPI, 2018)

Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein ...

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

González García, Ismael; Contreras, Cristina; Estévez Salguero, María Ánxela; Ruíz Pino, Francisco; Cosh, Benoit; Pensado Méndez, Iván; Liñares Pose, Laura; Rial Pensado, Eva; Blanco Martínez de Morentin, Pablo; Fernø, Johan; Diéguez González, Carlos; Nogueiras Pozo, Rubén; Le Stunff, Hervé; Magnan, Christophe; Tena Sempere, Manuel; López Pérez, Miguel Antonio (Elsevier, 2018)

Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The ...

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Glucagon, GLP-1 and thermogenesis

Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress