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Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake
Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein ...
Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress
Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The ...