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Glucagon, GLP-1 and thermogenesis

González García, Ismael; Milbank, Edward; Diéguez González, Carlos; López Pérez, Miguel Antonio; Contreras, Cristina (MDPI, 2019)

Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, ...

CPT1C in the ventromedial nucleus of thehypothalamus is necessary for brown fatthermogenesis activation in obesity

Rodríguez Rodríguez, Rosalía; Miralpeix, Cristina; Fosch, Anna; Pozo, Macarena; Calderón Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López Pérez, Miguel Antonio; Herrero, Laura; Serra, Dolors; Casals, Núria (Elsevier, 2019)

Objective:Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigatewhether CPT1C in the ventromedial nucleus of the hypothalamus (VMH) is involved in ...

Parabrachial Interleukin-6 reduces body weight and food intake and increases thermogenesis to regulate energy metabolism

Mishra, Devesh; Richard, Jennifer E.; Maric, Ivana; Porteiro Couto, Begoña; Häring, Martin; Kooijman, Sander; Musovic, Saliha; Eerola, Kim; López Ferreras, Lorena; Peris, Eduard; Grycel, Katarzyna; Shevchouk, Olesya T.; Micallef, Peter; Olofsson, Charlotta S.; Wernstedt Asterholm, Ingrid; Grill, Harvey J.; Nogueiras Pozo, Rubén; Skibicka, Karolina P. (Cell Press, 2019)

Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls energy balance and its role in obesity remain unclear. Here, ...

Thyroid-hormone-induced browning of white adipose tissue does not contribute to thermogenesis and glucose consumption

Johann, Kornelia; Cremer, Anna Lena; Fischer, Alexander W.; Heine, Markus; Rial Pensado, Eva; Resch, Julia; Nock, Sebastian; Virtue, Samuel; Harder, Lisbeth; Oelkrug, Rebecca; Astiz, Mariana; Brabant, Georg; Warner, Amy; Vidal Puig, Antonio; Oster, Henrik; Boelen, Anita; López Pérez, Miguel Antonio; Heeren, Joerg; Dalley, Jeffrey W.; Backes, Heiko; Mittag, Jens (Elsevier, 2019)

Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients ...