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Glucagon, GLP-1 and thermogenesis

González García, Ismael; Milbank, Edward; Diéguez González, Carlos; López Pérez, Miguel Antonio; Contreras, Cristina (MDPI, 2019)

Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, ...

CPT1C in the ventromedial nucleus of thehypothalamus is necessary for brown fatthermogenesis activation in obesity

Rodríguez Rodríguez, Rosalía; Miralpeix, Cristina; Fosch, Anna; Pozo, Macarena; Calderón Domínguez, María; Perpinyà, Xavier; Vellvehí, Miquel; López Pérez, Miguel Antonio; Herrero, Laura; Serra, Dolors; Casals, Núria (Elsevier, 2019)

Objective:Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigatewhether CPT1C in the ventromedial nucleus of the hypothalamus (VMH) is involved in ...

Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake

Liñares Pose, Laura; Rial Pensado, Eva; Estévez Salguero, María Ánxela; Milbank, Edward; González García, Ismael; Rodríguez, Claudia; Seoane Collazo, Patricia; Martínez Sánchez, Noelia; Nogueiras Pozo, Rubén; Prieto, Dolores; Diéguez González, Carlos; Contreras, Cristina; López Pérez, Miguel Antonio (MDPI, 2018)

Recent data have demonstrated that the hypothalamic GRP78/BiP (glucose regulated protein 78 kDa/binding immunoglobulin protein) modulates brown adipose tissue (BAT) thermogenesis by acting downstream on AMP-activated protein ...

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

González García, Ismael; Contreras, Cristina; Estévez Salguero, María Ánxela; Ruíz Pino, Francisco; Cosh, Benoit; Pensado Méndez, Iván; Liñares Pose, Laura; Rial Pensado, Eva; Blanco Martínez de Morentin, Pablo; Fernø, Johan; Diéguez González, Carlos; Nogueiras Pozo, Rubén; Le Stunff, Hervé; Magnan, Christophe; Tena Sempere, Manuel; López Pérez, Miguel Antonio (Elsevier, 2018)

Compelling evidence has shown that, besides its putative effect on the regulation of the gonadal axis, estradiol (E2) exerts a dichotomic effect on the hypothalamus to regulate food intake and energy expenditure. The ...