Now showing items 6-10 of 199

    • Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists 

      Val García, Cristina; Rodríguez García, Carlos; Prieto Díaz, Rubén; Crespo Gavilán, Abel; Azuaje Guerrero, Jhonny Alberto; Carbajales Pérez, Carlos; Majellaro, María; Díaz Holguín, Alejandro; Brea Floriani, José Manuel; Loza García, María Isabel; Gioé Gallo, Claudia; Contino, Marialessandra; Stefanachi, Angela; García Mera, Xerardo Xusto; Estévez Cabanas, Juan Carlos; Gutiérrez de Terán, Hugo; Sotelo, Eddy (ACS Publications, 2022)
      We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A1AR ligands. The most attractive ligands were confirmed as antagonists of ...
    • Study of plasma anti-CD26 autoantibody levels in a cohort of treatment-naïve early arthritis patients 

      Cordero Santamaría, Óscar Javier; Viéitez González, Irene; Altabás González, Irene; Nuño Nuño, Laura; Villalba Yllán, Alejandro; Novella Navarro , Marta; Peiteado López, Diana; Miranda-Carús, María-Eugenia; Balsa Criado, Alejandro; Varela Calviño, Rubén; Gómez Touriño, Iria María; Pego Reigosa, José María (Springer, 2022)
      In rheumatoid arthritis (RA), the identifcation of biomarkers to adjust treatment intensity and to correctly diagnose the disease in early stages still constitutes a challenge and, as such, novel biomarkers are needed. We ...
    • Activation of hypothalamic AMP-activated protein kinase ameliorates metabolic complications of experimental arthritis 

      Seoane Collazo, Patricia; Rial Pensado, Eva; Estévez Salguero, Ánxela María; Milbank, Edward; García Caballero, Lucía; Ríos García, Marcos; Liñares Pose, Laura; Scotece, Morena; Gallego Gómez, María Rosalía; Fernández-Real, Jose Manuel; Nogueiras Pozo, Rubén; Diéguez González, Carlos; Gualillo, Oreste; López Pérez, Miguel Antonio (Wiley, 2021)
      Objective: To investigate whether thermogenesis and the hypothalamus may be involved in the physiopathology of experimental arthritis (EA). Methods: EA was induced in male Lewis rats by intradermal injection of Freund's ...
    • Development of a biosensor based on a new marine luciferase fused to an affibody to assess Her2 expression in living cells 

      Rodriguez de la Fuente, Laura; Golán Cancela, Irene; Estévez Salguero, Ánxela María; Iglesias, Pablo; Costoya, José A. (Elsevier, 2022)
      The development of new diagnostic tools in tumor pathology allows the optimization of individualized therapies in cancer patients. The functional optical image provides a unique opportunity to identify the pathophysiological ...
    • Dopamine regulates adult neurogenesis in the ventricular-subventricular zone via dopamine D3 angiotensin type 2 receptor interactions 

      García Garrote, María; Parga Martín, Juan Andrés; Labandeira Guerra, Pablo José; Labandeira García, José Luis; Rodríguez Pallares, Jannette (Wiley, 2021)
      Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the ...





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