Now showing items 1-10 of 10

    • Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers 

      Novo Rodríguez, María de la Merced; Freire Rodríguez, Sonia; Al-Soufi, Wajih (Nature Publishing Group, 2018-01-29)
      The oligomers formed during the early steps of amyloid aggregation are thought to be responsible for the neurotoxic damage associated with Alzheimer’s disease. It is therefore of great interest to characterize this early ...
    • Fluorescence Emission of Pyrene in Surfactant Solutions 

      Piñeiro Maseda, Lucas; Novo Rodríguez, María de la Merced; Al-Soufi, Wajih (Elsevier, 2015)
      The systematic description of the complex photophysical behavior of pyrene in surfactant solutions in combination with a quantitative model for the surfactant concentrations reproduces with high accuracy the steady-state ...
    • Fluorescence-Labeled Bis-benzamidines as Fluorogenic DNA Minor-Groove Binders: Photophysics and Binding Dynamics 

      Bordello Malde, Jorge; Sánchez López, Mateo Isidro; Vázquez Sentís, Marco Eugenio; Mascareñas Cid, José Luis; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (WILEY-VCH Verlag GmbH, 2014-11-21)
      In recent decades there has been great interest in the design of highly sensitive sequence-specific DNA binders. The eligibility of the binder depends on the magnitude of the fluorescence increase upon binding, related to ...
    • Host-Guest Complexation Studied by Fluorescence Correlation Spectroscopy: Adamantane–Cyclodextrin Inclusion 

      Granadero, Daniel; Bordello Malde, Jorge; Pérez Alvite, María Jesús; Novo Rodríguez, María de la Merced; Al-Soufi, Wajih (MDPI, 2010)
      The host-guest complexation between an Alexa 488 labelled adamantane derivative and β-cyclodextrin is studied by Fluorescence Correlation Spectroscopy (FCS). A 1:1 complex stoichiometry and a high association equilibrium ...
    • Host-guest complexation studied by fluorescence correlation spectroscopy: adamantane–cyclodextrin inclusion 

      Granadero, Daniel; Bordello Malde, Jorge; Pérez Alvite, María Jesús; Novo Rodríguez, María de la Merced; Al-Soufi, Wajih (MDPI, 2010)
      The host-guest complexation between an Alexa 488 labelled adamantane derivative and β-cyclodextrin is studied by Fluorescence Correlation Spectroscopy (FCS). A 1:1 complex stoichiometry and a high association equilibrium ...
    • In Vivo Theranostics at the Peri-Infarct Region in Cerebral Ischemia 

      Agulla Freire, Jesús; Brea López, David; Campos Pérez, Francisco; Sobrino Moreiras, Tomás; Argibay González, Bárbara; Al-Soufi, Wajih; Blanco González, Miguel; Castillo Sánchez, José Antonio; Ramos Cabrer, Pedro (Ivyspring International Publisher, 2014)
      The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic ...
    • A model for monomer and micellar concentrations in surfactant solutions: application to conductivity, NMR, diffusion, and surface tension data 

      Al-Soufi, Wajih; Piñeiro Maseda, Lucas; Novo Rodríguez, María de la Merced (Elsevier, 2012)
      An empirical model for the concentrations of monomeric and micellized surfactants in solution is presented as a consistent approach for the quantitative analysis of data obtained with different experimental techniques from ...
    • Photophysical study of Thioflavin T as fluorescence marker of amyloid fibrils 

      Freire Rodríguez, Sonia; Araujo, Marcus H. de; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Elsevier, 2014)
      Thioflavin T is a highly sensitive fluorescent marker of amyloid fibrils that has been widely used for in vitro biomedical assays. However, neither its complex photophysical behavior nor its binding mode to amyloid fibrils ...
    • Towards Ratiometric Sensing of Amyloid Fibrils In Vitro 

      Freire Rodríguez, Sonia; Rodríguez Prieto, María de la Flor; Ríos Rodríguez, María del Carmen; Penedo Esteiro, Juan Carlos; Al-Soufi, Wajih; Novo Rodríguez, María de la Merced (Wiley, 2015)
      The aggregation of amyloid‐β peptide and its accumulation in the human brain has an important role in the etiology of Alzheimer’s disease. Thioflavin T has been widely used as a fluorescent marker for these amyloid aggregates. ...
    • Unveiling the multi-step solubilization mechanism of sub-micron size vesicles by detergents 

      Dalgarno, Paul A.; Juan-Colás, José; Hedley, Gordon J.; Piñeiro Maseda, Lucas; Novo Rodríguez, María de la Merced; Pérez González, Cibrán; Samuel, Ifor D. W.; Leake, Mark C.; Johnson, Steven; Al-Soufi, Wajih; Penedo, J. Carlos; Quinn, Steven D. (Nature Publishing Group, 2019)
      The solubilization of membranes by detergents is critical for many technological applications and has become widely used in biochemistry research to induce cell rupture, extract cell constituents, and to purify, reconstitute ...





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